Infertility treatments must respect three goods: the right to life and physical integrity of every human being from conception to natural death, the unity of marriage, and the specifically human values of sexuality (§12). They "are not to be rejected on the grounds that they are artificial", but all heterologous techniques, and homologous ones "which substitute for the conjugal act, are to be excluded", while techniques that aid the conjugal act are permitted (§12). Treatments "aimed at removing obstacles to natural fertilization" (hormonal treatment, surgery for endometriosis, unblocking the fallopian tubes) are licit; adoption and the prevention of sterility should be encouraged (§13).
Experience has shown that "all techniques of in vitro fertilization proceed as if the human embryo were simply a mass of cells to be used, selected and discarded": about a third of women have a baby, but the number of embryos sacrificed "is extremely high" (§14). Many losses are "foreseen and willed", and multiple embryo transfer "implies a purely utilitarian treatment of embryos" (§15). The Church "recognizes the legitimacy of the desire for a child", but it "cannot justify the 'production' of offspring" (§16). ICSI, a variety of IVF, is "intrinsically illicit" because it separates procreation completely from the conjugal act (§17). Freezing embryos "is incompatible with the respect owed to human embryos" (§18). For those already frozen, the Instruction rejects research, treatment, donation to infertile couples and, despite its good intention, "prenatal adoption": they are "a situation of injustice which in fact cannot be resolved" (§19). Freezing oocytes for artificial procreation is "morally unacceptable" (§20).
Embryo reduction is "an intentional selective abortion", and neither analogies with disasters nor the principles of the lesser evil or double effect justify it: "the end does not justify the means" (§21). Preimplantation diagnosis "is directed toward the qualitative selection and consequent destruction of embryos" and is "the expression of a eugenic mentality" (§22); "sick and disabled people are not some separate category of humanity" (§22). Interceptive methods act on the embryo before implantation and contragestative ones eliminate it once implanted; both "fall within the sin of abortion and are gravely immoral" (§23).